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Pantoprazole. Ed. Be sure that any discarded medicine is out of the reach of children. Precautions While Using This MedicineReturn to top It is important that your doctor check your progress at regular visits. If your condition does not improve, or if it becomes worse, check with your doctor.Side Effects of This MedicineReturn to top Side Effects of This Medicine Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Less common or rare Abdominal or stomach pain; blistering, loosening, peeling, or redness of skin; bull's eye-like rash on skin; changes in facial skin color; chest pain; diarrhea; difficulty in speaking; difficulty in urinating; discoloration, itching, numbness, pain, or redness at place of injection; fast or irregular breathing; increased frequency and volume of urination; infection; large, hive-like swellings on eyelids, face, lips, mouth, and or tongue; loosening and or stripping off of top layer of skin; loss of appetite ; loss of vision (sudden); nausea; painful urination; pain in joints or muscles; puffiness or swelling of the eyelids or around the eyes; shortness of breath, troubled breathing, tightness in chest, and or wheezing; skin rash, hives, and itching; skin tenderness with burning; unusual tiredness or weakness; unusual thirst; vomiting; yellow eyes or skin Incidence not known Blindness; bloody or cloudy urine; bloody, black or tarry stools; continuing vom pantoprazole		  

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E? How should I take this medicine? What if I miss a dose? What drug(s) may interact with pantoprazole? What side effects may I notice from taking pantoprazole? What should I watch for while taking pantoprazole? Where can I keep my medicine? What are pantoprazole tablets? (Back to top) PANTOPRAZOLE (PROTONIX®) prevents the production of acid in the stomach. It reduces symptoms and prevents injury to the esophagus or stomach in patients with gastroesophageal reflux disease (GERD) or ulcers. Pantoprazole is also useful in conditions that produce too much stomach acid such as Zollinger-Ellison syndrome. Generic pantoprazole tablets are not yet available. What should my health care professional know before I take pantoprazole? (Back to top) They need to know if you have any of these conditions:& 149;liver disease& 149;an unusual or allergic reaction to omeprazole, lansoprazole, pantoprazole, rabeprazole, other medicines, foods, dyes, or preservatives& 149;pregnant or trying to get pregnant& 149;breast-feeding How should I take this medicine? (Back to top) Take pantoprazole tablets by mouth. Follow the directions on the prescription label. Swallow the tablets whole with a drink of water; do not crush, break, or chew. Take your doses at regular intervals. Do not take your medicine more often than directed.Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose pantoprazole


pantoprazole News:
ION The active ingredient in PROTONIX ® (pantoprazole sodium) Delayed- Release Tablets is a substituted benzimidazole, sodium 5-( difluoromethoxy)- 2- ( 3,4- dimethoxy- 2- pyridinyl) methyl sulfinyl - 1 H- benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion. Its empirical formula is C16 H14 F2 N3 NaO4 S x 1.5 H2 O, with a molecular weight of 432.4. The structural formula is: Pantoprazole sodium sesquihydrate is a white to off- white crystalline powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium sesquihydrate is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n- hexane. The stability of the compound in aqueous solution is pH- dependent. The rate of degradation increases with decreasing pH. At ambient temperature, the degradation half- life is approximately 2.8 hours at pH 5.0 and approximately 220 hours at pH 7.8. PROTONIX is supplied as a delayed- release tab

pantoprazole S receiving pantoprazole for up to 8 weeks. Adverse Events in GERD Patients in Short-term International Trials % Incidence Study Event Pantoprazole Total (N=2805) Ranitidine 300 mg (N=594) Omeprazole 20 mg (N=474) Famotidine 40 mg (N=239) Headache 2 3 2 1 Diarrhea 2 2 2 <1 Abdominal pain 1 1 <1 <1 In two U. S. controlled clinical trials involving PROTONIX 10- pantoprazole, 20- pantoprazole, or 40- mg doses for up to 12 months pantoprazole, the following adverse events considered by investigators to be possibly pantoprazole, probably or definitely related to drug occurred in 1% or more of GERD patients on long- term therapy. Most Frequent Adverse Events Reported as Drug Related in Long- term Domestic Trials % Incidence Study Event PROTONIX (n = 536) Ranitidine (n = 185) Headache 5 2 Abdominal pain 3 1 Liver function tests abnormal 2 <1 Nausea 2 2 Vomiting 2 2 Note: Only adverse events with an incidence greater than or equal to the comparators are shown. In addition pantoprazole, in these short- and long- term domestic and international tr pantoprazole.

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pantoprazole E for adults is 40 mg daily for 4-8 weeks. It generally is recommended that tablets be taken approximately 30 minutes prior to meals for maximal effectiveness. Tablets should be swallowed whole and should not be crushed, split or chewed. DRUG INTERACTIONS: Pantoprazole is less likely than omeprazole to interact with other drugs. The absorption of certain drugs may be affected by stomach acidity, and, as a result, pantoprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively. PREGNANCY: Use of pantoprazole in pregnant women has not been adequately evaluated. NURSING MOTHERS: Pantoprazole has not been studied in nursing women. SIDE EFFECTS: Pantoprazole like other PPIs is well-tolerated. The most common side effects are diarrhea, nausea, vomitin

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