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Famotidine. Vere renal insufficiency, it may exceed 20 hours, reaching approximately 24 hours in anuric patients. Since CNS adverse effects have been reported in patients with moderate and severe renal insufficiency, to avoid excess accumulation of the drug in patients with moderate or severe renal insufficiency, the dose of PEPCID may be reduced to half the dose or the dosing interval may be prolonged to 36-48 hours as indicated by the patient’s clinical response. Based on the comparison of pharmacokinetic parameters for PEPCID in adults and pediatric patients, dosage adjustment in pediatric patients with moderate or severe renal insufficiency should be considered. HOW SUPPLIED No. 3535 — PEPCID Tablets, 20 mg, are beige colored, U-shaped, film-coated tablets coded MSD 963 on one side and PEPCID on the other. They are supplied as follows: NDC 0006-0963-31 unit of use bottles of 30 NDC 0006-0963-94 unit of use bottles of 90 NDC 0006-0963-58 unit of use bottles of 100 NDC 0006-0963-28 unit dose package of 100 NDC 0006-0963-82 bottles of 1,000 NDC 0006-0963-87 bottles of 10,000 NDC 0006-0963-72 carton of 25 UNIBLISTER™ cards of 31 tablets each. No. 3536 — PEPCID Tablets, 40 mg, are light brownish-orange, U-shaped, film-coated tablets coded MSD 964 on one side and PEPCID on the other. They are supplied as follows: NDC 0006-0964-31 unit of use bottles of 30 NDC 0006-0964-94 unit of use bottles of 90 NDC 0006-0964-58 unit of use bottles of 100 NDC 0006-0964-28 unit dose package of 100 NDC 0006-0964-82 bottles of 1,000 NDC 0006-0964-87 bottles of 10,000 NDC 0006-0964-
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Or ranitidine. Pregnancy—H 2-blockers have not been studied in pregnant women. In animal studies, famotidine and ranitidine have not been shown to cause birth defects or other problems. However, one study in rats suggested that cimetidine may affect male sexual development. More studies are needed to confirm this. Also, studies in rabbits with very high doses have shown that nizatidine causes miscarriages and low birth weights. Make sure your doctor knows if you are pregnant or if you may become pregnant before taking H 2-blockers. Breast-feeding—Cimetidine, famotidine, nizatidine, and ranitidine pass into the breast milk and may cause unwanted effects, such as decreased amount of stomach acid and increased excitement, in the nursing baby. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor. Children—This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults when used for short periods of time. Older adults—Confusion and dizziness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of H 2-blockers. Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are t
